Original ArticlePrognostic value of JAK3 promoter methylation and mRNA expression in clear cell renal cell carcinoma
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Graphical abstract
Keywords
Janus kinase 3
Renal cell carcinoma
Epigenetic biomarker
Tumor immune microenvironment
Tumor immune cell infiltration
Abbreviations
JAK3
Janus kinase 3
ccRCC
clear cell renal cell carcinoma
TCGA
The Cancer Genome Atlas
SYSUCC
Sun Yat-sen University Cancer Center
RCC
Renal cell carcinoma
CPTAC
The National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium
JAK-STAT
Janus kinase-signal transducer and activator of transcription
TPM
transcripts per million
GEO
Gene Expression Omnibus
IHC
immunohistochemistry
ssGSEA
single-sample gene-set enrichment analysis
EMT
epithelial mesenchymal transition
Pan-FTBRS
pan-fibroblast TGFβ response signature
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Peer review under responsibility of Cairo University.
- 1
These authors contributed equally to this article.
© 2022 The Authors. Published by Elsevier B.V. on behalf of Cairo University.